Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide basedcereblonligand and a linker used forPROTACBCL-XL degrader XZ739^[1].

XZ739, a CRBN-dependentPROTAC BCL-XL degraderwith aDC₅₀value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediatedapoptosis^[1].

527.54

C₂₂H₂₉N₃O₁₀S

2140807-24-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.