Cu(II)GTSM

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Cu(II)GTSM

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

68341-14-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Cu(II)GTSM 是一种细胞通透性铜复合物，可显著抑制GSK3β。Cu(II)GTSM 抑制 Amyloid-β 寡聚体(AβOs)，降低tau磷酸化。Cu(II)GTSM 也降低了 Amyloid-β 三聚体的丰度。Cu(II)GTSM 可以被作为一种潜在的抗癌和抗菌剂。

生物活性

Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibitsGSK3β. Cu(II)GTSM inhibitsAmyloid-βoligomers(AβOs)and decreasestauphosphorylation. Cu(II)GTSM also decreases the abundance ofAmyloid-βtrimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent^[1]^[2].

IC₅₀& Target^[2]

GSK3β

Amyloid-β oligomers

体外研究
(In Vitro)

Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.
Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%^[2].

Western Blot Analysis^[2]

Cell Line:	SH-SY5Y cells
Concentration:	25 μM
Incubation Time:	2 hours
Result:	Inhibits GSK3β and decreases Tau phosphorylation.

体内研究
(In Vivo)

Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice^[2].

Animal Model:	AD mice (K670N, M671L; 5-6 months old)^[2]
Dosage:	10 mg/kg
Administration:	Daily; p.o.
Result:	Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.

分子量

293.86

Formula

C₆H₁₀CuN₆S₂

CAS 号

68341-14-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.