TBK1/IKKε-IN-1 is a dualTBK1andIKKεinhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, hasIC₅₀s of<100 nM.

IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response^[1].

498.53

C₂₈H₂₆N₄O₅

2058264-32-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.