Pralidoxime

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Pralidoxime

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6735-59-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Pralidoxime 是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂。Pralidoxime 通过肟部分对结合神经毒剂磷中心的亲核攻击，重新激活受神经毒剂抑制的 AChE。Pralidoxime 是一种有机磷中毒的解毒剂。

生物活性

Pralidoxime is a potent reactivator ofacetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibitedAChEvia direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning^[1]^[2].

体内研究
(In Vivo)

Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice^[3].

Animal Model:	F1B6D2 mice (male, administered subcutaneously diethylparaoxon)^[3]
Dosage:	10, 50, 100, and 150 mg/kg
Administration:	Intramuscular administration, once
Result:	Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.

Clinical Trial

分子量

137.16

Formula

C₇H₉N₂O⁺

CAS 号

6735-59-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.