Dichlorphenamide disodium

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

76382-13-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Diclofenamide disodium

产品介绍

Dichlorphenamide (Diclofenamide) disodium 是一种具有口服活性的，特异性，碳酸酐酶 (carbonic anhydrase) 抑制剂，可以通过抑制眼睛中水的分泌，从而降低眼压，可用于青光眼的研究。

生物活性

Dichlorphenamide (Diclofenamide) disodium is an orally active, specific,carbonic anhydraseinhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research^[1].

体内研究
(In Vivo)

Dichlorphenamide disodium can reduce IOP locally in male albino rabbits^[1].

Animal Model:	Male albino rabbits (approximately 2.5 kg)^[1]
Dosage:	50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg
Administration:	Eye drop of 50 μL or oral gavage of 2 mg/kg or 6 mg/kg，5 hours
Result:	Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration. And demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.

Clinical Trial

分子量

351.14

Formula

C₆H₆Cl₂N₂Na₂O₄S₂

CAS 号

76382-13-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.