NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor ofaldehyde dehydrogenase1A1 (ALDH1A1), inhibits hALDH1A1 withIC₅₀of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2,IC₅₀>57 μM)^[1][2].

IC50: 40 nM (hALDH1A1)^[2]

NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant^[1].

NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts^[1].

452.98

C₂₁H₃₃ClN₆O₃

2080306-22-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.