ALDH1A3-IN-1

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ALDH1A3-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1695970-90-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

ALDH1A3-IN-1 (Compound 14) 是一个有效的ALDH1A3抑制剂，其IC₅₀值为 0.63 μM，K_i值为 0.46 μM。ALDH1A3-IN-1 能被用于研究前列腺癌 (prostate cancer)。

生物活性

ALDH1A3-IN-1 (Compound 14) is a potentALDH1A3inhibitor, with anIC₅₀of 0.63 μM and aK_iof 0.46 μM. ALDH1A3-IN-1 can be studied inprostatecancer^[1].

IC₅₀& Target

ALDH1A3

0.63 μM (IC₅₀)

ALDH1A1

7.08 μM (IC₅₀)

ALDH3A1

8.00 μM (IC₅₀)

ALDH1A3

0.46 μM (Ki)

ALDH1A3

26.92 μM (Km)

体外研究
(In Vitro)

ALDH1A3-IN-1 (Compound 14) (0-200 μM, 96 h) shows antiproliferative activity in prostate cancer cell lines^[1].
ALDH1A3-IN-1 (0-200 μM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner^[1].

Cell Proliferation Assay^[1]

Cell Line:	PC3, LNCaP, and DU145 cells
Concentration:	12.5-200 μM
Incubation Time:	96 h
Result:	Showed antiproliferative activity with IC₅₀values of 47 ± 6, 25 ± 1, and 61 ± 5 μM against PC3, LNCaP, and DU145 cells.

Cell Viability Assay^[1]

Cell Line:	Primary cells cultured at early passage from human prostate tissue biopsies
Concentration:	50 and 200 μM
Incubation Time:	72 h
Result:	Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.

分子量

284.19

性状

Liquid

Formula

C₁₃H₁₈BrNO

CAS 号

1695970-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)