Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is aGluR5 receptorantagonist. Topiramate produces its antiepileptic effects through enhancement ofGABAergicactivity, inhibition ofkainate/AMPAreceptors, inhibition of voltage-sensitivesodium and calcium channels, increases inpotassiumconductance, and inhibition ofcarbonic anhydrase^[1][2][3].

Topiramate lithium has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors^[2].

346.30

C₁₂H₂₁LiNO₈S

488127-53-3

托吡酯锂

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