| CAS NO: | 317-34-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 420.43 |
|---|---|
| Formula | C16H24N10O4 |
| CAS No. | 317-34-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 53 mg/mL (126.1 mM) |
| Water: 84 mg/mL (199.8 mM) | |
| Ethanol: <1 mg/L | |
| Chemical Name | 1,3-Dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine |
| Synonyms | Cardophyllin; Aminophyllin; Aminophylline; Theophyllamine; Phyllocontin; Euphyllin; Truphylline; Minomal R 175 mg tab; Minomal R 350 mg tab; Minomal SR 600 mg tab Chemical Name: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1) InChi Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2 SMILES Code: CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN |
| In Vitro | In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells. Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist. |
|---|---|
| References | Acad Emerg Med. 2003 Mar;10(3):192-7. |
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