Gabapentin

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Gabapentin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60142-96-3

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

加巴喷丁

产品介绍

Gabapentin 是一种口服有效的 P/Q 型 Ca²⁺通道阻滞剂。Gabapentin 抑制神经元 Ca²⁺内流和减少神经递质释放。Gabapentin 是 GABA 类似物，可用于缓解神经性疼痛。

生物活性

Gabapentin is a potent, orally activeP/Q type Ca²⁺channelblocker. Gabapentin inhibits neuronal Ca²⁺influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain^[1]^[2]^[3].

体外研究
(In Vitro)

Gabapentin (0-300 μM) produces a concentration-dependent inhibition of the K⁺-induced [Ca²⁺]_iincrease in synaptosomes (IC₅₀=14 μM; maximal inhibition by 36%)^[1].
Gabapentin (100 μM) decreases the K⁺-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively^[1].
Gabapentin (0-1000 μM) reduces the K⁺-evoked [³H]-noradrenaline release in neocortical slices (IC₅₀=48 μM; maximal inhibition of 46%) but not from synaptosomes^[1].

体内研究
(In Vivo)

Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks^[2].
Gabapentin (1-100 mg/kg; i.p.; once; male mice) has analgesic effect and reduces writhing in a dose-dependent manner^[3].

Animal Model:	Male BALB/c mice (35-45 g)^[2]
Dosage:	5 and 10 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Increased the time spent in target quadrant and decreased the distance to platform in MWM test . Decreased the transfer latency on second day in mEPM test . Prolonged retention latency in PA test .

Animal Model:	Male mice (26-30 g)^[3]
Dosage:	1, 5, 10, 50 and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Produced 45-70% inhibition of writhing.

Clinical Trial

分子量

171.24

性状

Solid

Formula

C₉H₁₇NO₂

CAS 号

60142-96-3

中文名称

加巴喷丁；盖巴潘汀；卡巴番定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL(291.99 mM;Need ultrasonic)

DMSO : 1 mg/mL(5.84 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	5.8398 mL	29.1988 mL	58.3976 mL
5 mM	1.1680 mL	5.8398 mL	11.6795 mL
10 mM	0.5840 mL	2.9199 mL	5.8398 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (145.99 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。