B-Raf IN 10

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B-Raf IN 10

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1425485-87-5

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

B-Raf IN 10 (Compound C09) 是一种BRAF抑制剂，IC₅₀在 50-100 nM。B-Raf IN 10 具有抗肿瘤活性。

生物活性

B-Raf IN 10 (Compound C09) is aBRAFinhibitor with anIC₅₀between 50 and 100 nM. B-Raf IN 10 shows antitumor activity^[1].

IC₅₀& Target^[1]

BRAF-V600E

< 50 nM (IC₅₀)

Braf

50-100 nM (IC₅₀)

体外研究
(In Vitro)

B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E^[1].
B-Raf IN 10 shows an IC₅₀between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E^[1].
B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells^[1].

Cell Viability Assay^[1]

Cell Line:	A375, SK-MEL-28, SK-MEL-31 and CHL-1
Concentration:
Incubation Time:	72 h
Result:	Showed inhibition with IC₅₀s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.

分子量

494.49

性状

Solid

Formula

C₂₂H₂₁F₃N₄O₄S

CAS 号

1425485-87-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(202.23 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0223 mL	10.1114 mL	20.2229 mL
5 mM	0.4045 mL	2.0223 mL	4.0446 mL
10 mM	0.2022 mL	1.0111 mL	2.0223 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。