ERK5-IN-3 (compound 33j) is a potent and selectiveERK5(extracellular signal-related kinase 5) inhibitor, with anIC₅₀of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with anIC₅₀of 31 nM^[1].

ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min^[1].

489.37

C₂₄H₂₃Cl₂FN₄O₂

1888305-85-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.