PM-81I

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PM-81I

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1637532-83-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PM-81I 是一种有效的STAT6抑制剂 (靶向SH2结构域)，能有效降低STAT6磷酸化水平。PM-81I 可用于过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症的研究。

生物活性

PM-81I is a potentSTAT6inhibitor (targeting theSH2structural domain) that effectively reducesSTAT6phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease orcancer^[1].

IC₅₀& Target

STAT6^[1].

体外研究
(In Vitro)

PM-81I (0.05, 0.1, 0.5, 1, 2.5, 5 μM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Bease-2B immortalized human epithelial airway cells^[1].

Western Blot Analysis^[1]

Cell Line:	Bease-2B immortalized human epithelial airway cells
Concentration:	0.05, 0.1, 0.5, 1, 2.5, 5 μM
Incubation Time:	2 h
Result:	Decreased phosphorylation levels of STAT6 to18%, 13%, 13% when at 1, 2.5 and 5 μM, respectively.

分子量

845.91

Formula

C₄₃H₅₈F₂N₃O₁₀P

CAS 号

1637532-83-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.