EGFR-IN-61

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EGFR-IN-61

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

EGFR-IN-61 (compound 22a) 是一种有效的EGFR激酶抑制剂，IC₅₀值分别为 42 nM (L858R/T790 M)、137 nM (L858R/T790 M/C797S) 和 743 nM (WT)。 EGFR-IN-61 对 A549 和 H1975 细胞具有抗增殖活性，IC₅₀分别为 2.14 和 1.82 μM。

生物活性

EGFR-IN-61 (compound 22a) is a potentEGFRkinase inhibitor, withIC₅₀values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, withIC₅₀values of 2.14 and 1.82 μM, respectively^[1].

IC₅₀& Target

EGFR^L858R/T790M

42 ± 2 nM (IC₅₀)

EGFR^{L858R/T790M/C797S}

137 ± 6 nM (IC₅₀)

EGFR (WT)

743 ± 20 nM (IC₅₀)

体外研究
(In Vitro)

EGFR-IN-61 (compound 22a) shows excellent kinase selectivity against the L858R/T790M/C797S mutant EGFR kinase rather than the wild-type, which reached 5.4 times^[1].

分子量

629.15

Formula

C₃₃H₃₇ClN₈O₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.