pan-HER-IN-1

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pan-HER-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1639040-94-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

pan-HER-IN-1 (Compound C5) 是一种不可逆的、具有口服活性的广谱HER抑制剂。对EGFR、HER4、EGFR^T790M/L858R和HER2的IC₅₀分别为 0.38、1.6、2.2 和 3.5 nM。pan-HER-IN-1 诱导细胞凋亡 (apoptosis)，表现出抗肿瘤活性。

生物活性

pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HERinhibitor withIC₅₀values of 0.38, 1.6, 2.2 and 3.5 nM againstEGFR,HER4,EGFR^T790M/L858RandHER2, respectively. pan-HER-IN-1 inducesapoptosisand shows antitumor activities^[1].

IC₅₀& Target

EGFR

0.38 nM (IC₅₀)

HER4

1.6 nM (IC₅₀)

EGFR^{L858R/T790M/C797S}

2.2 nM (IC₅₀)

HER2

3.5 nM (IC₅₀)

分子量

408.25

Formula

C₁₉H₁₄BrN₅O

CAS 号

1639040-94-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.