Dimaprit dihydrochloride is a selectivehistamine H2 receptoragonist, it also inhibitsnNOSwith anIC₅₀of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion^[1][2].

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors^[1].
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC₅₀of 49±14 μM^[2].

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)^[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate^[1].

234.19

C₆H₁₇Cl₂N₃S

23256-33-9

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