Hydrocortisone phosphate

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CAS NO:

3863-59-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Hydrocortisone 21-phosphate
Cortisol 21-phosphate

产品介绍

Hydrocortisone phosphate (Hydrocortisone 21-phosphate)，一种糖皮质激素，是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone phosphate 抑制IL-6和IL-3的生物活性，IC₅₀值分别为 6.7 和 21.4 μM。Hydrocortisone phosphate 可用于溃疡性结肠炎 (UC) 的研究。

生物活性

Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, withIC₅₀s of 6.7 and 21.4 μM forIL-6andIL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC)^[1]^[2]^[3].

IC₅₀& Target^[1]

IL-3

IL-6

6.7 μM (IC₅₀)

IL-3

21.4 μM (IC₅₀)

体外研究
(In Vitro)

Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC₅₀s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells^[3].
Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures^[3].

体内研究
(In Vivo)

Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice^[2].

Animal Model:	Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis^[2]
Dosage:	30 mg/kg
Administration:	P.o. twice daily for 5 days
Result:	Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.

Clinical Trial

分子量

442.44

Formula

C₂₁H₃₁O₈P

CAS 号

3863-59-0

中文名称

磷酸氢化可的松

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.