| CAS NO: | 31430-15-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 313.28 |
|---|---|
| Formula | C16H12FN3O3 |
| CAS No. | 31430-15-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 3 mg/mL (9.6 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: methyl (5-(4-fluorobenzoyl)-1H-benzo[d]imidazol-2-yl)carbamate InChi Key: CPEUVMUXAHMANV-UHFFFAOYSA-N InChi Code: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22) SMILES Code: O=C(OC)NC1=NC2=CC(C(C3=CC=C(F)C=C3)=O)=CC=C2N1 |
| Synonyms | Flumoxanal, NSC 313680; NSC 313680; NSC313680; NSC-313680; R 17899; R17899; R-17899 |
| In Vitro | In vitro activity: Flubendazole results in morphological changes included contraction of the soma region, formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. Flubendazole have a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). Flubendazole and Albendazole shows similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL. |
|---|---|
| In Vivo | Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes. |
| Animal model | Birds |
| Formulation & Dosage | 6.32, 7.83, 31.33 mg/kg/day |
| References | Parasitol Res. 2006 Mar;98(4):317-23; Reprod Toxicol. 2014 Nov;49:33-42. |
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