POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor ofcomplement factor C3activation. POT-4 can be used for age-related macular degeneration research^[1][2]

A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b^[2].

1627.85

Solid

C₇₂H₁₀₂N₂₂O₁₈S₂

934461-40-2

Ac-ICV{Trp(Me)}QDWGAHRCT-NH2 (Disulfide bridge:Cys2-Cys12)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)