Anthramycin

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Anthramycin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

4803-27-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Anthramycin 是一种有效的抗生素 (antibiotic)，属于苯并二氮杂卓 (PBD) 家族。Anthramycin 具有强大的抗肿瘤 (antitumor) 活性。在小鼠中枢神经系统中，Anthramycin 可作为胆收缩素 (cholecystokinin) 的有效拮抗剂。

生物活性

Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potentantibiotic. Anthramycin has potentantitumoractivity. Anthramycin can act as an potent antagonist ofcholecystokininin the central nervous system in mice^[1]^[2]^[3].

体外研究
(In Vitro)

ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC^[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria^[3].

体内研究
(In Vivo)

Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice^[2].
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart^[3].

Animal Model:	Male ddY mice (20 ± 2 g, 12-14 each group)^[2]
Dosage:	0, 0.3, and 0.5 mg/kg
Administration:	IP, once, 10 min before the intracisternal (i.c.) injection of CCK
Result:	Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).

Animal Model:	Female CFN Gif rats (140-180 g)^[3]
Dosage:	0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
Administration:	SC, daily for 8 days
Result:	Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.

分子量

315.32

Formula

C₁₆H₁₇N₃O₄

CAS 号

4803-27-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.