6-Iodopravadoline (AM630) TFA is a selective cannabinoidCB2receptorantagonist (K_i=31.2 nM) that displays 165-fold selectivity overCB1receptors. 6-Iodopravadoline TFA attenuates the ability of a number of cannabinoids to inhibit electrically-evoked twitches of the mouse isolated vas deferens^[1][2].

6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.; Swiss ICR mice) TFA significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day; Swiss ICR mice) TFA produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used^[3].

618.38

C₂₅H₂₆F₃IN₂O₅

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