Irindalone is a novel serotonin5-HT₂antagonist.

Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT₂receptors and about a 10 times lower affinity for α₁-adrenoceptors^[1].

Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs^[1].

408.51

C₂₄H₂₉FN₄O

96478-43-2

茚达酮

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