Abaperidone is a potent antagonist of5-HT_2A receptoranddopamineD₂receptorwithIC₅₀s of 6.2 and 17 nM.

Abaperidone possesses good affinity for dopamine D₂receptors, together with a greater affinity for 5-HT₂receptors with IC₅₀of 17 and 6.2 nM, reaspectively^[1].

The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs^[1].

452.47

C₂₅H₂₅FN₂O₅

183849-43-6

阿巴哌酮

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.