Clocapramine is an antagonist of theD₂,5-HT_2Areceptors.

Clocapramine has a moderate affinity for D₂-receptors in vitro. Clocapramine shows higher affinity for 5-HT_2Athan for D₂-receptors in vitro^[1].

Clocapramine shows the lowest potency for D₂-occupancy in vivo^[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D₂and frontal serotonin-5-HT₂receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT₂versus D₂receptors that fall between these two groups (ED₅₀of 14.5 mg/kg for D₂, 4.9 mg/kg for 5-HT₂)^[2].

481.07

C₂₈H₃₇ClN₄O

47739-98-0

氯卡帕明；氯卡比咪嗓；罗卡普胺

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