SB-215505

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SB-215505

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

162100-15-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SB-215505 是一种有效的，亚型选择性5-HT_2B受体拮抗剂，对 5-HT_2B，5-HT_2A，5-HT_2C的pK_i值分别为 8.3、6.77、7.66。SB-215505 可以增加大鼠的清醒和运动活动。

生物活性

SB-215505 is a potent and subtype-selective5-HT_2Breceptor antagonist withpK_ivalues of 8.3, 6.77, 7.66 for 5-HT_2B, 5-HT_2A, 5-HT_2C, respectively^[1]. SB-215505 increases wakefulness and motor activity in rats^[2].

IC₅₀& Target^[1]

5-HT_2BReceptor

8.3 (pKi)

5-HT_2AReceptor

6.77 (pKi)

5-HT_2CReceptor

7.66 (pKi)

体外研究
(In Vitro)

SB-215505 is 30 fold selective for the 5-HT_2Bover the 5-HT_2Areceptor, and only marginally selective over the 5-HT_2Creceptor^[1].

体内研究
(In Vivo)

SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2^[2].

Animal Model:	Male Sprague-Dawley rats weighing 230-260 g^[2]
Dosage:	0.1, 0.3 and 1.0 mg/kg
Administration:	IP; two doses (4 days between two doses)
Result:	Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.

分子量

337.80

Formula

C₁₉H₁₆ClN₃O

CAS 号

162100-15-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.