SB 258719 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1217674-10-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SB 258719 hydrochloride 是一种选择性的5-HT₇受体拮抗剂，与该受体亲和度高(pK_i=7.5)。SB-258719 hydrochloride 可以用于癌症和神经系统疾病的研究。

生物活性

SB 258719 hydrochloride is a selective5-HT₇receptor antagonist displayed high affnity (pK_i=7.5) for the receptor. SB-258719 hydrochloride can be used for the research ofcancerand neurological diseases^[1]^[2].

IC₅₀& Target^[1]

5-HT₇Receptor

7.5 (pKi)

体外研究
(In Vitro)

SB-258719 (1, 3 and 10 μM; HEK 293 cells) hydrochloride produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT^[1].

体内研究
(In Vivo)

SB-258719 (5~20 mg/kg; i.p.) hydrochloride significantly attenuates the 5-CT-induced hypothermia^[2].

Animal Model:	Male Swiss Webster mice (20~25 g)^[2].
Dosage:	5~20 mg/kg
Administration:	I.p.
Result:	Significantly attenuated the 5-CT-induced hypothermia.

分子量

374.97

Formula

C₁₈H₃₁ClN₂O₂S

CAS 号

1217674-10-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.