Metoclopramide hydrochloride is a potent and orally active antagonist of5-HT₃anddopamine D2 receptor, withIC₅₀s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis^[1][2].

Metoclopramide (0.01-10 μM) hydrochloride stimulates aldosterone release in isolated perfused rat zona glomerulosa cells^[3].
Metoclopramide hydrochloride results in prokinesis by four mechanisms: inhibition of presynaptic D2 receptors and stimulation of presynaptic excitatory 5-HT4 receptors, thereby allowing acetylcholine (ACh) release from intrinsic cholinergic motor neurons; inhibition of D2 postsynaptic receptors; and antagonism of the presynaptic inhibition of muscarinic receptors, leading to further augmentation of ACh release^[2].

Metoclopramide (6.7 μg/g; s.c. daily for 50 days) hydrochloride significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle^[4].
Metoclopramide (5-40 mg/kg; i.p.) hydrochloride induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice^[5].
Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride induces stereotyped cage climbing behaviour in mice^[5].

336.26

C₁₄H₂₃Cl₂N₃O₂

7232-21-5

盐酸甲氧氯普胺；盐酸胃复安

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Please store the product under the recommended conditions in the Certificate of Analysis.