GR127935 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	148642-42-6
包装:	5mg
市场价:	3800元

产品介绍

GR127935 hydrochloride 是一种有效且具有口服活性的5-HT1D和5-HT1B受体拮抗剂，pK_i值均为 8.5。GR127935 hydrochloride 对 5-HT1B/1D 受体的选择性是 5-HT1A、5-HT2A 和 5-HT2C 受体的 100 倍。GR127935 hydrochloride 可用于神经疾病研究。

生物活性

GR127935 hydrochloride is a potent and orally active5-HT1Dand5-HT1B receptorantagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used inneurological diseaseresearch^[1]^[2].

IC₅₀& Target^[1]

5-HT_1BReceptor

8.5 (pKi)

5-HT_1DReceptor

8.5 (pIC₅₀)

分子量

534.05

性状

Solid

Formula

C₂₉H₃₂ClN₅O₃

CAS 号

148642-42-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)