cis-Urocanic acid is a5-HT2A receptoragonist. cis-Urocanic acid binds to5-HT receptorwith relatively high affinity (K_d=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor^[1].

Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic^[1].

138.12

Solid

C₆H₆N₂O₂

7699-35-6

顺式-尿刊酸

Room temperature in continental US; may vary elsewhere.

H₂O : 50 mg/mL(362.00 mM;Need ultrasonic)

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