Mycophenolate Mofetil

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

128794-94-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

Mycophenolate mofetil (RS 61443) 是霉酚酸的吗啉代乙酯前药。 Mycophenolate mofetil 通过抑制肌苷一磷酸脱氢酶 (IMPDH) 来抑制从头嘌呤合成。 Mycophenolate mofetil 显示选择性淋巴细胞抗增殖作用涉及 T 细胞和 B 细胞，防止抗体形成。

Cas No.	128794-94-5
别名	吗替麦考酚酯; RS 61443; TM-MMF
化学名	2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
Canonical SMILES	CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)OCCN3CCOCC3)OC
分子式	C₂₃H₃₁NO₇
分子量	433.49
溶解度	≥ 16.25 mg/mL in DMSO, ≥ 15.68 mg/mL in EtOH with ultrasonic
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Mycophenolate Mofetil is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) with IC50s of 39 nM and 27 nM, respectively. References: [1]. Nakanishi, T., et al., Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10(1): p. 91-7. [2]. Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36(7): p. 598-611. [3]. Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol, 2012. 37(1): p. 48-54.