| CAS NO: | 1421227-52-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 569.58 |
|---|---|
| Formula | C28H30F3N7O3 |
| CAS No. | 1421227-52-2 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (175.6 mM) |
| Water:<1 mg/mL | |
| Ethanol: 80 mg/mL warmed (140.5 mM) | |
| Other | Chemical Name: N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N InChi Code: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39) SMILES Code: CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1 |
| Synonyms | WS-3; WS 3; WS3; |
| In Vitro | In vitro activity: WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. WS3 reversibly induces proliferation of primary fetal and adult human retinal pigment epithelial (RPE) cells. Cell Assay: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Chem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11. |
 |  |
m.cnreagent.com