GSK-J1 lithium salt is a potent inhibitor ofH3K27me3/me2-demethylases JMJD3/KDM6BandUTX/KDM6A, withIC₅₀of 60 nM towards KDM6B.

IC50: 60 nM (KDM6B)^[2]

GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner^[1]. GSK-J1 inhibits the demethylase activity of KDM5C with 8.5-fold increased potency compared with that of KDM5B at 1 mM α-ketoglutarate, with IC₅₀of 11 μM and 94 μM, respectively^[3].

395.38

C₂₂H₂₂LiN₅O₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.