Lifitegrast (SAR 1118) sodium is a potentintegrinantagonist. Lifitegrast sodium blocks the binding ofintercellular adhesion molecule 1 (ICAM-1)to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment toICAM-1with anIC₅₀of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease^[1].

Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses^[1].
Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀of 2.98 nM^[1].

Lifitegrast has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killedP. aeruginosaandS. aureusin the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior^[2].

637.46

C₂₉H₂₃Cl₂N₂NaO₇S

1119276-80-0

立他司特钠

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.