PLN-1474 (compound 1) is an orally active and selectiveavss1integrininhibitor with anIC₅₀value of ＜50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or treating a fibrotic or cirrhotic disease or disorder^[1].

IC50: ＜50 nM (ανβ1), ＜50 nM (ανβ6)^[1]

PLN-1474 inhibits ανβ1 and ανβ6 with IC₅₀s of ＜50 nM by solid phase assay^[1].

PLN-1474 (10 μM) decreases the expression level of profibrotic genes, including COL1A1 and TIMP1 in liver^[1].
PLN-1474 significantly reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in a mouse model of liver fibrosis^[1].
PLN-1474 (6-12 weeks) prophylactically or therapeutically blocks SMAD3 phosphorylation and significantly decreases OHP levels, collagen gene expression, and collagen deposition examined histologically in the CDAHFD NASH mouse model^[1].

431.57

Solid

C₂₄H₃₇N₃O₄

2408065-32-5

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 83.33 mg/mL(193.09 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。