AT-1002 是一种 6 聚体合成肽，是一种紧密连接 (junction) 的调节剂和吸收增强剂。
| 生物活性 | AT-1002, a 6-mer synthetic peptide[1], is a tightjunctionregulator and absorption enhancer[2]. |
体外研究
(In Vitro) | AT-1002, a 6-mer synthetic peptide, belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1].
Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2].
Cell Viability Assay[2] | Cell Line: | Caco-2 cells | | Concentration: | 0 to 5 mg/mL | | Incubation Time: | 3 or 24 hours | | Result: | Treatment for up to 3 h did not affect cell viability at any concentration. Reduced cell viability after 24 h at concentrations of 2.5 mg/mL and higher. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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