MPC-0767 is a potent, selective, and orally activehsp90inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability^[1].

MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the T_max, C_max, AUC and F% are 1 (h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively^[1].
MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals^[1].
MPC-0767 is well tolerated when administered at 252 mg/kg po (equivalent to 200 mg/kg dose of MPC-3100)^[1].

734.64

C₂₆H₃₆BrN₇O₉S₂

1310540-32-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.