HDAC-IN-40 is a potent alkoxyamide-basedHDACinhibitor withK_ivalues of 60 nM and 30 nM forHDAC2andHDAC6, respectively. HDAC-IN-40 had antitumor effects^[1].

HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC₅₀values of 0.89 μM and 0.72 μM, respectively^[1].
HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR^[1].
HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation^[1].

326.34

Solid

C₁₅H₂₂N₂O₆

2463198-51-6

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 250 mg/mL(766.07 mM;Need ultrasonic)

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