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NS309
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NS309图片
CAS NO:18711-16-5
包装与价格：
包装价格(元)
5mg电议
50mg电议

产品介绍
NS309 是 Ca2+- 激活的 SK/IK 钾通道的有效和选择性激活剂，但在 BK 通道上没有显示活性。
Cas No.18711-16-5
别名3-肟-6,7-二氯-1H-吲哚-2,3-二酮,NS 309;NS-309
化学名6,7-dichloro-3-(hydroxyamino)-2H-indol-2-one
Canonical SMILESO=C1N=C2C(Cl)=C(Cl)C=CC2=C1NO
分子式C8H4Cl2N2O2
分子量231.04
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.IC50 value: Ca2+-activated K+ channelTarget:

References:
[1]. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin
[2]. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448.
[3]. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508
[4]. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.