Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is aPI3Kδinhibitor, which is the less active enantiomer of TGR-1202.

Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC₅₀) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC₅₀with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)^[1].

571.55

Solid

C₃₁H₂₄F₃N₅O₃

1532533-69-9

Room temperature in continental US; may vary elsewhere.