ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with anIC₅₀value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level ofATRand its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targetingATRkinase^[1].

441.55

C₂₂H₂₇N₅O₃S

Room temperature in continental US; may vary elsewhere.

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