Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is ap53reactivator with anticancer effects. Roslin 2 bromide bindsFAK, disrupts the binding ofFAKand p53^[1].

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins^[1].

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53^+/+but not in HCT116 p53^-/-xenografts in vivo^[1].

311.22

C₁₃H₁₉BrN₄

29574-21-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.