Belotecan hydrochloride (CKD-602 hydrochloride), aTopoisomeraseIinhibitor, is a synthetic camptothecin derivative.

Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC₅₀values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells^[1]. Belotecan shows a significant anticancer effect on glioma cells, with IC₅₀values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG^[2].

Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group^[3].

469.96

Solid

C₂₅H₂₈ClN₃O₄

213819-48-8

盐酸贝洛替康

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 12.5 mg/mL(26.60 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。