Pyridoclax is a potentialMcl-1inhibitor.

Pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, Pyridoclax induces apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells^[1]. Pyridoclax directly binds to Mcl-1, and hence sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies. Pyridoclax induces apoptosis in ovarian, and also in lung, and mesothelioma cancer cells when it is administrated in combination with Bcl-xL-targeting siRNA or Bcl-xL targeting molecules such as ABT-737 or its orally available derivative ABT-263^[2].

426.51

Solid

C₂₉H₂₂N₄

1651890-44-6

Room temperature in continental US; may vary elsewhere.

DMSO : 20 mg/mL(46.89 mM;Need ultrasonic)

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