SSTR5 antagonist 2 TFA

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1254733-98-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SSTR5 antagonist 2 TFA (compound 10) 是强效的、具有口服活性的生长激素抑制激素(受体)亚型 5 (SSTR5) 的选择性拮抗剂，有潜力用于 2 型糖尿病的研究。

生物活性

SSTR5Antagonist 1 (compound 10) is a highly potent, oral active andselective somatostatin (receptor) subtype 5 (SSTR5)antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)^[1].

IC₅₀& Target

SSTR5^[1].

体内研究
(In Vivo)

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg^[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors^[1].

Animal Model:	Rodent diabetic model without risk of hypoglycemia^[1].
Dosage:	10 mg/kg.
Administration:	Orally.
Result:	Increased both total and active circulating incretin hormone GLP1 levels.

分子量

660.65

Formula

C₃₄H₃₆F₄N₂O₇

CAS 号

1254733-98-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.