BnO-PEG6-OH is anon-cleavable6 unit PEGADClinker used in the synthesis ofantibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-basedPROTAClinker can be used in the synthesis ofPROTACs^[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

372.45

Liquid

C₁₉H₃₂O₇

24342-68-5

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