m-PEG5-CH2COOH

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m-PEG5-CH2COOH

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

16142-03-3

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1 g	电议

产品介绍

m-PEG5-CH2COOH 是一种不可降解 (non-cleavable) 的 ADC linker，用于抗体偶联药物 (ADC) 的合成。m-PEG5-CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

生物活性

m-PEG5-CH2COOH is anon-cleavableADC linker used in the synthesis ofantibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

Non-cleavable

PEGs

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

310.34

性状

Liquid

Formula

C₁₃H₂₆O₈

CAS 号

16142-03-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month