| CAS NO: | 1180-71-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 470.51 |
|---|---|
| Formula | C26H30O8 |
| CAS No. | 1180-71-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 44 mg/mL (93.5 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: (4aS,6aR,8aR,8bR,9aS,12S,12aS,14aR,14bR)-12-(furan-3-yl)-6,6,8a,12a-tetramethyldecahydro-1H,3H-oxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(6H,9aH)-trione InChi Key: KBDSLGBFQAGHBE-MSGMIQHVSA-N InChi Code: InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1 SMILES Code: O=C1C[C@]2([H])OC(C)(C)[C@]3([H])CC([C@@]4(C)[C@@]56[C@@](O6)([H])C(O[C@@H](C7=COC=C7)[C@]5(C)CC[C@]4([H])[C@@]23CO1)=O)=O |
| Synonyms | Citro; Dictamnolactone; NSC36508; Limonin; Evodin; Limonine; NSC-36508; NSC 36508; Obaculactone. |
| In Vitro | In vitro activity: Limonin is a furanolactone enriched in citrus fruits, which has antivirus and antitumor ability. Limonin inhibits the replication of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM. Limonin also shows antinociceptive and anti-inflammatory effects in vivo. Limonin is a potent anti proliferative agent against human hepatoma HepG2 cells via regulation of apoptosis and Wnt signallings. Cell Assay: When culturing the HIV-1 in human peripheral blood mononuclear cells (PBMC) and monocytes/macrophages (M/M), Limonin inhibit the HIV-1 replication in all cellular systems and inhibit HIV-1 replication with EC50 value of 60u μM in PBMC cells in a dose-dependent way. In human hepatoma HepG2 cells, limonin can induced apoptosis, which was evidenced by WB analysis of some apoptosis factors. |
|---|---|
| In Vivo | In the female Syrian hamsters treated with DMBA, which can cause tumor, limonin showed a 60% reduction in tumor burden. It decreased 20% tumor number and 50% tumor mass. In male F344 rats treated with azoxymethane (AOM), 0.05% limonin in diet significantly reduced (65%-92% inhibition) the incidence of colonic adenocarcinoma. Thus, limonin has chemopreventive effects on chemically induced carcinogenesis. |
| Animal model | Female Syrian hamsters and rats |
| Formulation & Dosage | 0.05% limonin in diet |
| References | Carcinogenesis. 1989 Aug;10(8):1535-7; Biofactors. 2000;13(1-4):213-8. |
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