| CAS NO: | 314-13-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 960.81 |
|---|---|
| Formula | C34H24N6O14S4.4Na |
| CAS No. | 314-13-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (104.1 mM) |
| Water: 100 mg/mL (104.1 mM) | |
| Ethanol: <1 mg/mL | |
| SMILES | [O-]S(C1=CC(S([O-])(=O)=O)=C2C=CC(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(O)C6=C(N)C(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C6C=C5)C(C)=C4)C=C3C)=C(O)C2=C1N)(=O)=O.[Na+].[Na+].[Na+].[Na+] |
| Synonyms | Direct Blue 53 |
| In Vitro | In vitro activity: Evans Blue is found to be inhibiting DNA binding of NF-κB at a low concentration of 100 μM. It has proven over the years to be a dependable stain for microscopic determination of cell death. Evans Blue is also a known blocker of a subset of a-amino-3-hydroxy-5-methyl-isoxazole/kainate receptors (IC50=355 nM) for the subunit combination GluR1,2. Evans blue is the first known δ-subunit-specific antagonist of ENaC and activates large-conductance Ca2+-activated K+ channels in sheep bladder myocytes and cultured endothelial cells of human umbilical veins. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Evans blue pretreatment could inhibit the mast cells degranulation and that may be the main mechanism for prevent animals from C48/80-triggered anaphylaxis and systemic inflammation. Evans blue modulates the non-N-methyl-d-aspartate receptor in rat thalamic neurons, blocks the P2X-purinergic receptor in rat vas deferens, and inhibits the glutamate transporter in rat brain synaptic vesicles. |
| Animal model | CD hairless rats |
| Formulation & Dosage | Dissolved in saline; 100 mg/kg; i.p. |
| References | Bioorg Med Chem Lett. 2004 Dec 20;14(24):6123-7; J Pharmacol Exp Ther. 2005 Nov;315(2):965-9. |
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