m-PEG6-NHS ester

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m-PEG6-NHS ester

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1449390-12-8

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1 g	电议

产品介绍

m-PEG6-NHS ester 是一种不可降解 (non-cleavable) 的含 6 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG6-NHS ester 是一种 PROTAC linker，属于 PEG/Alkyl/ether 类，可用于合成 PROTAC 分子。

生物活性

m-PEG6-NHS ester is anon-cleavable6 unit PEGADClinker used in the synthesis ofantibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-basedPROTAClinker can be used in the synthesis ofPROTACs.

IC₅₀& Target

PEGs

Alkyl/ether

Non-cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

分子量

421.44

性状

Liquid

Formula

C₁₈H₃₁NO₁₀

CAS 号

1449390-12-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month