Amino-PEG2-C2-acid is acleavable3 unit PEGADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-basedPROTAClinker that can be used in the synthesis ofPROTACs^[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

177.20

Solid

C₇H₁₅NO₄

791028-27-8

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